ASIS International (ASIS) Professional Certified Investigator Practice Exam

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How long after death does brain damage typically begin to occur?

2 minutes
4 minutes
10 minutes
15 minutes

The correct answer is: 4 minutes

Brain damage typically begins to occur around four minutes after death due to the cessation of blood flow and oxygen supply to the brain. The brain is highly sensitive to oxygen deprivation, and neuronal cells can start to suffer irreversible damage shortly after oxygen levels drop. While some preliminary cellular damage begins almost immediately after the heart stops, more significant and irreversible changes are noted at approximately this four-minute mark. This understanding is crucial in various investigative and forensic contexts, as it helps determine the time of death and the condition of the brain cells at the time of post-mortem examinations and investigations.