ASIS International (ASIS) Professional Certified Investigator Practice Exam

What is the HLa Dq Alpha gene associated with?

1. Polymorphisms in DNA

2. Coding for proteins

3. Categorization of genetic traits

4. None of the above

The correct answer is: Polymorphisms in DNA

The HLA DQ alpha gene is primarily associated with polymorphisms in DNA. Polymorphisms refer to variations in the DNA sequence that occur among individuals within a population. These variations can influence how the immune system functions, as the HLA (human leukocyte antigen) gene complex plays a crucial role in the immune response. HLA genes are key in presenting peptide fragments to T cells, which are vital for the adaptive immune response. The diversity of these genes, represented by polymorphisms, is critical for the body's ability to recognize and respond to various pathogens. The other options provide different aspects of genetics but do not specifically address the association of the HLA DQ alpha gene with polymorphisms. For instance, while the HLA DQ gene does code for proteins, its more prominent aspect in this context relates to the genetic variability (polymorphisms) that impacts immune function rather than just the coding itself. Similarly, while categorization of genetic traits can be part of understanding genetics, it doesn't capture the primary focus of polymorphisms associated with the HLA DQ alpha gene. Thus, the most precise association is with polymorphisms in DNA.